Sodium Hydroxide → 4,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine

HRID 637930

Reaction equation

[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[OH-].[Na+].[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1>C(O)C>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][S:3][C:2]2[N:4]=[C:5]([OH:6])[CH:7]=[C:8]([OH:9])[N:1]=2)=[CH:16][CH:15]=1

Participants

Conditions

Temperature: 60 °C

Procedure

To a suspension of thiobarbituric acid (15 g) in 50% ethanol (180 ml) are added a solution of NaOH (5.1 g) in 50% ethanol (75 ml) and p-methoxybenzyl chloride (18.7 g). The mixture is heated under stirring for 60' at 60° C.; then it is cooled and the solid is filtered by suction, washed with water; then dried over CaCl2, yielding 15 g of 2-p-methoxy-benzylthio-4,6-dihydroxypyrimidine.

Workup

temperatureThe mixture is heated
temperaturethen it is cooled
filtrationthe solid is filtered by suction
washwashed with water
dry with materialthen dried over CaCl2

Sources & evidence

ORD record: ord-5d6de63010204f47b9d61cc676dd9f97
Source dataset: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04559345

Linked notes

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