N-methylpiperidine-4-carboxamide → 1-[6-Fluoro-2-(4-chlorophenyl)-4-quinolinyl]-N-methyl-4-piperidinecarboxamide

HRID 638288

Reaction equation

HRID 638288 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH:3]=1.[CH3:20][NH:21][C:22](=[O:29])[CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[C:4]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:3]=[C:2]2[N:26]1[CH2:27][CH2:28][CH:23]([C:22]([NH:21][CH3:20])=[O:29])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 2760460N-methylpiperidine-4-carboxamideHCID 136038954-Chloro-2-(4-chlorophenyl)-6-fluoroquinoline

Product 1

HCID 202536581-[6-Fluoro-2-(4-chlorophenyl)-4-quinolinyl]-N-methyl-4-piperidinecarboxamide

Procedure

The named compound was made in a manner analogous to that of Example 4(c) using 4-chloro-2-(4-chlorophenyl)-6-fluoroquinoline, prepared as described in Example 4(b), and N-methylisonipecotamide as starting materials. It was obtained as colorless needles, mp 279°-282°dec on recrystallization from pyridine.

Workup

  1. customprepared
  2. customIt was obtained as colorless needles, mp 279°-282°dec
  3. customon recrystallization from pyridine

Sources & evidence

ORD record
ord-628f7fed6f23474d894b2aaff018b534
Source dataset
uspto-grants-1985_12
Patent number
US04560692

Linked notes

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