HCID 394241, compound → 5-Methylimidazo[2,1-b]benzothiazole-2-methanol

Reaction equation

[CH3:1][C:2]1[C:7]2[N:8]3[CH:13]=[C:12]([C:14](OCC)=[O:15])[N:11]=[C:9]3[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][C:2]1[C:7]2[N:8]3[CH:13]=[C:12]([CH2:14][OH:15])[N:11]=[C:9]3[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 394241HCID 394241, compound

HCID 21226445Aluminium lithium hydride

Product 1

HCID 118168225-Methylimidazo[2,1-b]benzothiazole-2-methanolYield 69%

Procedure

5-methyl imidazo[2,1-b]-benzthiazole-2-methanol was prepared according to the procedure outlined in Example 1, (Step 2). Starting from ethyl 5-methylimidazo[2,1-b]-benzthiazole-2-carboxylate (5.2 g, 20 mmol) and LiAlH4 solution (22 ml, 0.5 M solution in THF), 3 g (69% yield) of the alcohol derivative was isolated as a brown solid. (M+H) 219.

Workup

custom5-methyl imidazo[2,1-b]-benzthiazole-2-methanol was prepared

Sources & evidence

ORD record: ord-35491ae8d70942eea2f66f8f8ca845d0
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07691842B2

Reaction notes

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