Methyl 2-amino-2-ethylbutanoate → 2-Ethyl-2-{[6-(2-methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carbonyl]-amino}-butyric acid methyl ester

HRID 639331

Reaction equation

HRID 639331 reaction equation
OC[C@@H](NC(C1C=NC(N2CCCC2)=C(OCCC)N=1)=O)CC(C)C.[CH3:26][O:27][CH2:28][CH2:29][O:30][C:31]1[N:36]=[C:35]([C:37]([OH:39])=O)[CH:34]=[N:33][C:32]=1[N:40]1[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1.[CH3:46][O:47][C:48](=[O:55])[C:49]([NH2:54])([CH2:52][CH3:53])[CH2:50][CH3:51]>>[CH3:46][O:47][C:48](=[O:55])[C:49]([CH2:52][CH3:53])([NH:54][C:37]([C:35]1[CH:34]=[N:33][C:32]([N:40]2[CH2:45][CH2:44][O:43][CH2:42][CH2:41]2)=[C:31]([O:30][CH2:29][CH2:28][O:27][CH3:26])[N:36]=1)=[O:39])[CH2:50][CH3:51]

Participants

4

Reactant 3

HCID 13412527Methyl 2-amino-2-ethylbutanoateHCID 248312586-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amideHCID 685666496-(2-Methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid

Product 1

HCID 248317402-Ethyl-2-{[6-(2-methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carbonyl]-amino}-butyric acid methyl ester

Procedure

In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-(2-methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid and 2-amino-2-ethyl-butyric acid methyl ester (European Journal of Medicinal Chemistry 1984, 19, 261). m/z (ES+): 411.5 (M+H).

Sources & evidence

ORD record
ord-50f3d431ee1d41149e1e69e81fbb1c00
Source dataset
uspto-grants-2010_04
Patent number
US07691863B2

Linked notes

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