7-(benzyloxy)-2,3,4,5-tetrahydro-1H-3-benzazepine → 7-[(2-Fluoro-4-iodophenyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine

HRID 641566

Reaction equation

HRID 641566 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[O:9][C:10]1[CH:27]=[CH:26][C:13]2[CH2:14][CH2:15][N:16](C(OC(C)(C)C)=O)[CH2:17][CH2:18][C:12]=2[CH:11]=1.C(OC1C=CC2CCNCCC=2C=1)C1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[O:9][C:10]1[CH:27]=[CH:26][C:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18][C:12]=2[CH:11]=1

Participants

3

Reactant 2

HCID 574376177-(benzyloxy)-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 589845721,1-Dimethylethyl 7-[(2-fluoro-4-Iodophenyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Product 1

HCID 589845767-[(2-Fluoro-4-iodophenyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine

Procedure

The title compound was prepared from 1,1-dimethylethyl 7-[(2-fluoro-4-iodophenyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (E274, Step 3) using an analogous method to that described for Description 2 (D2). MS (ES+) m/e 384 [M+H]+.

Sources & evidence

ORD record
ord-fc8c3d13fc6d4e3ea7b1caba009f7b6f
Source dataset
uspto-grants-2010_04
Patent number
US07696193B2

Linked notes

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