5-Iodoisatin → HCID 178517222, compound
Reaction equation
[I:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:23][NH2:24])(=[O:22])=[O:21])=[CH:16][C:15]=1[N+:25]([O-:27])=[O:26]>C(O)(=O)C>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:23][N:24]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([I:1])[CH:3]=3)[NH:7][C:6]2=[O:11])(=[O:22])=[O:21])=[CH:16][C:15]=1[N+:25]([O-:27])=[O:26]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-chloro-3-nitrobenzenesulfonohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 78 mg of the title compound (77%) as a yellow solid in 73% purity by HPLC (Rt: 3.65, 5.39, gradient of 8 min, MaxPlot detection between 230 and 400 nm).