HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Ethyl Ketone → 3-(4-(3,4-Dichlorophenyl)piperazine-1-yl)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Product | 3-(4-(3,4-Dichlorophenyl)piperazine-1-yl)propan-1-ol | HCID 13097930 | — |
Reaction Steps
Compound 5 (0.32 mL, 3.54 mmols) was mixed with 4-(3,4-dichlorophenyl)piperazine (0.58 g, 2.5 mmols) and potassium carbonate (0.78 g, 5.6 mmols) in 15 ml 2-butanone overnight at 85° C. as described in General Procedure B to yield compound 7p and was used as is for the next reaction. MS (LC/MS, ESI): 289 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447122B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b2b44e96151540e98a8efe67154bbde0 |
| Source note | uspto-grants-2016_09 |