(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine → [4-(Pyridin-2-ylmethoxy)-phenyl]-(2-(R)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

HRID 642208

Reaction equation

HRID 642208 reaction equation
CO[C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[CH:6][CH:5]=1.[NH:19]1[CH2:23][CH2:22][CH2:21][C@@H:20]1[CH2:24][N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([N:19]2[CH2:23][CH2:22][CH2:21][C@@H:20]2[CH2:24][N:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:18])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 853151(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 2416604Methyl 4-(pyridin-2-ylmethoxy)benzoate

Product 1

HCID 11494329[4-(Pyridin-2-ylmethoxy)-phenyl]-(2-(R)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Procedure

The title compound is prepared in a manner substantially analogous to Procedure F from 4-(Pyridin-2-ylmethoxy)-benzoic acid methyl ester and 1-[(2R)-2-pyrrolidinylmethyl]pyrrolidine [CAS 60419-23-0]. MS (ES+) 366.3

Sources & evidence

ORD record
ord-25ea42b5f6b54d00981c0423ccc671dd
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Linked notes

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