4-(Benzyloxy)benzoic acid → HCID 178509390, compound

HRID 64266

Reaction equation

HRID 64266 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:18][C:19]1[NH:23][N:22]=C(C2C=CC(OC3C=CC=CC=3)=CC=2)[C:20]=1[C:37]#[N:38]>>[NH2:18][C:19]1[NH:23][N:22]=[C:13]([C:12]2[CH:16]=[CH:17][C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:10][CH:11]=2)[C:20]=1[C:37]#[N:38]

Participants

3

Reactant 2

HCID 738804-(Benzyloxy)benzoic acidHCID 178509389HCID 178509389, compound

Product 1

HCID 178509390HCID 178509390, compound

Procedure

The desired product was prepared from 4-(benzyloxy)benzoic acid according to the procedures similar to those (step 1 to 3) for 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile under appropriate conditions recognized by one of ordinary skill in the art. 1H NMR (400 MHz, DMSO-d6) δ 12.01 (s, 1H), 7.72 (d, J=8.8 Hz, 2H), 7.50-7.44 (m, 2H), 7.44-7.37 (m, 2H), 7.36-7.32 (m, 1H), 7.11 (d, J=7.2 Hz, 2H), 6.39 (br s, 2H) and 5.16 (s, 2H).

Sources & evidence

ORD record
ord-9d3ab2e2655f49399e011c7ac61de0ce
Source dataset
uspto-grants-2016_09
Patent number
US09447106B2

Linked notes

Loading…