Phosphorus tribromide → 4-(Bromomethyl)-2-chloro-3-methylbenzonitrile

Participants

Role	Name	HCID	Charge
Reactant	Phosphorus tribromide	HCID 24614	—
Reactant	2-Chloro-4-(hydroxymethyl)-3-methylbenzonitrile	HCID 68577571	—
Solvent	Dichloromethane	HCID 6344	—
Product	4-(Bromomethyl)-2-chloro-3-methylbenzonitrile	HCID 68577413	—

Reaction Conditions

Temperature	-15 °C

Reaction Steps

To a solution of compound 7B (700 mg, 3.9 mmol) in CH2Cl2 (15 mL) was added PBr3 (5.8 mL, 5.8 mmol, 1N in CH2Cl2) at −15° C., and stirred at −15° C. for 3 hr. The reaction was slowly quenched with saturated NaHCO3 solution at −15° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07696241B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-a46c7acaaea94ee58f98a39797973cdf
Source note	uspto-grants-2010_04