1-Benzyl-4-(hydroxymethyl)piperidin-4-ol → 4-(Hydroxymethyl)piperidin-4-ol
Reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][OH:16])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[OH:16][CH2:15][C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A suspension of 26.0 g (117 mmol) 1-benzyl-4-hydroxymethyl-piperidin-4-ol and 5.0 g 10% Pd/C in 500 mL MeOH was hydrogenated at 50° C. and 3 bar hydrogen pressure until the theoretical hydrogen uptake had occurred (4 h). The catalyst was filtered off and washed with MeOH. After the solvent had been eliminated the residue was reacted further without purification.
Workup
- customwas hydrogenated at 50° C.
- custom(4 h)
- filtrationThe catalyst was filtered off
- washwashed with MeOH
- customwas reacted further without purification
Sources & evidence
- ORD record
- ord-296e78c1935344c180208533e9baa118
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07696195B2
Reaction notes
Loading…