4-(1-Benzylpiperidin-4-yl)morpholine → 4-Morpholinopiperidine

HRID 642910

Reaction equation

HRID 642910 reaction equation
C1(C[N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[CH2:10][CH2:9]2)C=CC=CC=1.[H][H]>CO.[Pd]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 7838314-(1-Benzylpiperidin-4-yl)morpholineHCID 178418361HCID 178418361, compound

Product 1

HCID 7957244-Morpholinopiperidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

41.59 g (0.16 Mol) 4-[1-(phenylmethyl)-4-piperidinyl]-morpholine (N) are dissolved in 400 mL methanol, combined with 5.2 g palladium on activated charcoal (10%) and hydrogenated for 18 hours at ambient temperature with 50 psi hydrogen. The catalyst is filtered off and the filtrate is evaporated down. A colourless oil remains, which crystallises after a short time.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated down
  3. customA colourless oil remains, which crystallises after a short time

Sources & evidence

ORD record
ord-002e7a9350934f3ca9561e62fd89d388
Source dataset
uspto-grants-2010_04
Patent number
US07696346B2

Linked notes

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