Dextroamphetamine → Lisdexamfetamine Dimesylate

HRID 643241

Reaction equation

HRID 643241 reaction equation
[S:1]([OH:5])(O)(=[O:3])=[O:2].[NH2:6][CH:7]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:8].[NH2:16][C@H:17]([C:23](O)=[O:24])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22].[CH3:26][C@H](N)CC1C=CC=CC=1.[CH3:36][C@H](N)CC1C=CC=CC=1>O>[CH3:8][C@H:7]([NH:6][C:23]([C@@H:17]([NH2:16])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])=[O:24])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH3:26][S:1]([OH:5])(=[O:3])=[O:2].[CH3:36][S:1]([OH:5])(=[O:3])=[O:2]

Participants

5

Reactant 3

HCID 5826Dextroamphetamine2×HCID 222898AmphedrineHCID 131727865L-lysine d-amphetamine

Product 1

HCID 11597697Lisdexamfetamine Dimesylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Male Sprague-Dawley rats were provided water ad libitum, fasted overnight, and dosed by oral gavage with 1.5, 3, 6, 12, and 60 mg/kg of amphetamine sulfate or L-lysine-d-amphetamine containing the equivalent amounts of d-amphetamine. Concentrations of d-amphetamine were measured by ELISA.

Sources & evidence

ORD record
ord-e49b75f9167f4493828b512bab7809bf
Source dataset
uspto-grants-2010_04
Patent number
US07700561B2

Linked notes

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