4'-Chloro-4-biphenylol → 4-(4'-Chloro-biphenyl-4-yloxymethyl)-thiazole-2-carboxylic acid

HRID 643810

Reaction equation

HRID 643810 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C([O:17][C:18]([C:20]1[S:21][CH:22]=[C:23]([CH2:25]Cl)[N:24]=1)=[O:19])C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:25][C:23]3[N:24]=[C:20]([C:18]([OH:19])=[O:17])[S:21][CH:22]=3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 915894'-Chloro-4-biphenylolHCID 10822129Ethyl 4-(chloromethyl)-1,3-thiazole-2-carboxylate2×

Product 1

HCID 112448944-(4'-Chloro-biphenyl-4-yloxymethyl)-thiazole-2-carboxylic acid

Procedure

4-(4′-Chloro-biphenyl-4-yloxymethyl)-thiazole-2-carboxylic acid was prepared using general procedure B from 4-chloro-4′-hydroxybiphenyl (available from TCI America, Portland, Oreg.) and 4-chloromethyl-thiazole-2-carboxylic acid ethyl ester (Intermediate 4). Yield: 71 mg. Mass spectrum (ES) MH+=346.

Sources & evidence

ORD record
ord-c1ee13d8cdd54bb787aa1bd0050cd3e1
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Linked notes

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