HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-N-(5-chloropyridin-2-yl)benzamide → 2-[4-(B enzyloxy)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-N-(5-chloropyridin-2-yl)benzamide | HCID 21906381 | — |
| Reactant | 4-Benzyloxy-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid | HCID 68535719 | — |
| Product | 2-[4-(B enzyloxy)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 68532666 | — |
Reaction Steps
Using methods substantially equivalent to those described in Example 1-F, 4-benzyloxy-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid (529 mg, 1.27 mmol) and N-(5-chloropyridin-2-yl)-2-aminobenzamide (297 mg, 1.20 mmol) afforded, after purification by chromatography (SiO2: EtOAc in hexanes), 493 mg (63%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-b362c472deaa453eac5060bc7a1ee1e1 |
| Source note | uspto-grants-2010_04 |