5-Bromo-2-acetylsalicylic acid → 2-Acetoxy-5-bromo-N-(4,5-diethyloxazol-2-yl)benzamide

Reaction equation

[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([OH:9])=O)(=[O:3])[CH3:2].[NH2:15][C:16]1[O:17][C:18]([CH2:23][CH3:24])=[C:19]([CH2:21][CH3:22])[N:20]=1>>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([NH:15][C:16]1[O:17][C:18]([CH2:23][CH3:24])=[C:19]([CH2:21][CH3:22])[N:20]=1)=[O:9])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 739225-Bromo-2-acetylsalicylic acid

HCID 178601934,5-Diethyloxazol-2-amine

Product 1

HCID 178601192-Acetoxy-5-bromo-N-(4,5-diethyloxazol-2-yl)benzamideYield 22%

Procedure

Using 2-acetoxy-5-bromobenzoic acid and 2-amino-4,5-diethyloxazole as the raw materials, the same operation as the Example 24 gave the title compound.

Sources & evidence

ORD record: ord-81861e5635e44eb79acd9ae1804ee049
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700655B2

Reaction notes

Loading…