5-Bromosalicylic acid → HCID 86595540, compound

Reaction equation

[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[CH3:12][O:13][C:14](=[O:28])[CH2:15][C:16]1[S:20][C:19]([NH2:21])=[N:18][C:17]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH3:12][O:13][C:14](=[O:28])[CH2:15][C:16]1[S:20][C:19]([NH:21][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[OH:11])=[N:18][C:17]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

Reactant 2

HCID 69725-Bromosalicylic acid

HCID 18946572Methyl 2-(2-amino-4-phenylthiazol-5-yl)acetate

Product 1

HCID 86595540HCID 86595540, compoundYield 32.1%

Procedure

Using 5-bromosalicylic acid and 2-amino-4-phenylthiazole-5-acetic acid methyl ester as the raw materials, the same operation as the Example 195(3) gave the title compound.

Sources & evidence

ORD record: ord-c2d07f24fd9e40e8a29b8ea6c1587477
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700655B2

Reaction notes

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