2-(Acetyloxy)-5-chlorobenzoic acid → Benzamide,2-(acetyloxy)-5-chloro-n-1(2h)-pyridazinyl-

Reaction equation

[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:6]=1[C:7]([OH:9])=O)(=[O:3])[CH3:2].[NH2:15][N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][NH:17]1>>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:6]=1[C:7]([NH:15][N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][NH:17]1)=[O:9])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 28208132-(Acetyloxy)-5-chlorobenzoic acid

HCID 222262352-Aminopyridazine

Product 1

HCID 23069950Benzamide,2-(acetyloxy)-5-chloro-n-1(2h)-pyridazinyl-Yield 19.7%

Procedure

Using 2-acetoxy-5-chlorobenzoic acid and 2-aminopyridazine as the raw materials, the same operation as the Example 198(3) gave the title compound.

Sources & evidence

ORD record: ord-5d4f82d8b53d46649b3ce8b8c6aebb42
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700655B2

Reaction notes

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