1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 4-(4-(Trifluoromethyl)phenyl)-1,3-thiazol-2-amine
Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH3:10])=[CH:5][CH:4]=1.[NH2:14][C:15]([NH2:17])=[S:16]>>[NH2:17][C:15]1[S:16][CH:10]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=2)[N:14]=1Participants
3
Procedure
Using 4′-(trifluoromethyl)acetophenone and thiourea as the raw materials, the same operation as the Example 395(1) gave the title compound.
Sources & evidence
- ORD record
- ord-3f0e646ad3894f0e8ba95cded9d4b5ee
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700655B2
Reaction notes
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