5-Chlorosalicylic Acid → HCID 23069959, compound

Reaction equation

[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)[N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=2)[N:17]=1)=[O:9]

Participants

Reactant 2

HCID 94475-Chlorosalicylic Acid

HCID 27377414-(4-(Trifluoromethyl)phenyl)-1,3-thiazol-2-amine

Product 1

HCID 23069959HCID 23069959, compoundYield 16%

Procedure

Using 5-chlorosalicylic acid and 2-amino-4-[4-(trifluoromethyl)phenyl]thiazole as the raw materials, the same operation as the Example 16 gave the title compound.

Sources & evidence

ORD record: ord-9bafeca9f0f14dedb31c2878e7369365
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700655B2

Reaction notes

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