1-(2,5-Difluorophenyl)ethan-1-one → 4-(2,5-Difluorophenyl)-1,3-thiazol-2-amine

HRID 644487

Reaction equation

HRID 644487 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=O)[CH3:10].[NH2:12][C:13]([NH2:15])=[S:14]>>[NH2:15][C:13]1[S:14][CH:10]=[C:9]([C:3]2[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=2[F:1])[N:12]=1

Participants

3

Reactant 2

HCID 747941-(2,5-Difluorophenyl)ethan-1-oneHCID 2723790Thiourea

Product 1

HCID 20640894-(2,5-Difluorophenyl)-1,3-thiazol-2-amineYield 77.8%

Procedure

Using 2′,5′-difluoroacetophenone and thiourea as the raw materials, the same operation as the Example 395(1) gave the title compound.

Sources & evidence

ORD record
ord-fef72665099a40caaa4b8b16b1184265
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Linked notes

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