4'-Methoxyacetophenone → 2-Amino-4-(4-methoxyphenyl)thiazole
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH3:10])=[CH:5][CH:4]=1.[NH2:12][C:13]([NH2:15])=[S:14]>>[NH2:15][C:13]1[S:14][CH:10]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:12]=1Participants
3
Procedure
Using 4′-methoxyacetophenone and thiourea as the raw materials, the same operation as the Example 395(1) gave the title compound.
Sources & evidence
- ORD record
- ord-165c080030b04fa9a6f1a3ddfe14a777
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700655B2
Reaction notes
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