tert-Butyl piperazine-1-carboxylate → 1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride

HRID 645754

Reaction equation

HRID 645754 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[CH3:14][S:15]([CH2:18][CH2:19]COS(C)(=O)=O)(=[O:17])=[O:16].[ClH:26].Cl.COCC(NC(=O)CN1CCNCC1)C>>[ClH:26].[ClH:26].[CH3:14][S:15]([CH2:18][CH2:19][CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)(=[O:17])=[O:16]

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 102627583-(Methylsulfonyl)propyl methanesulfonateHCID 67245894N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride

Product 1

HCID 498534791-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride

Procedure

1-(3-Methanesulfonyl-propyl)-piperazine dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine and methanesulfonic acid 3-methanesulfonyl-propyl ester (prepared according to Baerlocher, F. J. et al. Aust. J. Chem. 1999, 52, 167-172) in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).

Sources & evidence

ORD record
ord-2d00d5a416a84e138dbe3dd3a13d688f
Source dataset
uspto-grants-2010_04
Patent number
US07705007B2

Linked notes

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