Chloroacetyl chloride → N-methoxy-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

HRID 645765

Reaction equation

[C:1]([O:5]C(N1CCNCC1)=O)(C)(C)C.[Cl:14]CC(Cl)=O.CONC.[ClH:23].Cl.COC[CH:28]([NH:30][C:31](=[O:39])[CH2:32][N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)C>>[ClH:14].[ClH:23].[CH3:1][O:5][N:30]([CH3:28])[C:31](=[O:39])[CH2:32][N:33]1[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]1

Participants

Reactant 4

HCID 6577Chloroacetyl chloride

HCID 14232N,O-Dimethylhydroxylamine

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 67245894N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride

Product 1

HCID 86613637N-methoxy-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

Procedure

N-Methoxy-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-methoxy-N-methylamine in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).

Sources & evidence

ORD record: ord-2f4faab9eaa54b9b96f7b431e40b78ab
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705007B2

Linked notes

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