Chloroacetyl chloride → N-Isopropyl-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

HRID 645767

Reaction equation

[C:1](OC(N1CCNCC1)=O)(C)(C)C.[Cl:14]CC(Cl)=O.C(NC)(C)C.[ClH:24].Cl.CO[CH2:28][CH:29]([NH:31][C:32](=[O:40])[CH2:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)[CH3:30]>>[ClH:14].[ClH:24].[CH:29]([N:31]([CH3:1])[C:32](=[O:40])[CH2:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)([CH3:30])[CH3:28]

Participants

Reactant 4

HCID 6577Chloroacetyl chloride

HCID 78485N-Methylisopropylamine

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 67245894N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride

Product 1

HCID 67246261N-Isopropyl-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

Procedure

N-Isopropyl-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-isopropyl-N-methylamine in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).

Sources & evidence

ORD record: ord-1585f7f5f9694b81a8add5fb1cf3b3a8
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705007B2

Linked notes

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