Chloroacetyl chloride → N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

HRID 645769

Reaction equation

C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:14]C[C:16](Cl)=[O:17].[C:19]([CH2:21][CH2:22][NH:23][CH3:24])#[N:20].[ClH:25].Cl.COCC(NC(=O)CN1CCNCC1)C>>[ClH:14].[ClH:25].[C:19]([CH2:21][CH2:22][N:23]([CH3:24])[C:16](=[O:17])[CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)#[N:20]

Participants

Reactant 4

HCID 6577Chloroacetyl chloride

HCID 69656Propanenitrile, 3-(methylamino)-

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 67245894N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride

Product 1

HCID 67246240N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

Procedure

N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-(2-cyanoethyl)-N-methylamine in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).

Sources & evidence

ORD record: ord-30200bc3bafe4949a91d69ff1e13ca80
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705007B2

Linked notes

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