HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ganciclovir → Ganciclovir Di-O-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ganciclovir | HCID 135398740 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | Ganciclovir Di-O-acetate | HCID 135459822 | 181.5% |
Reaction Steps
A mixture of 3.00 g of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, 300 mg of 4-dimethylaminopyridine, and 100 ml of acetic anhydride was vigorously stirred for 3 days at room temperature. The acetic anhydride was removed by evaporation at reduced pressure and the residue recrystallized from methanol to give 3.62 g of 9-(1,3-diacetyloxy-2-propoxymethyl)guanine, m.p. 237°-239° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04609661 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-ecab7526a4804b5087d56676e3c0b192 |
| Source note | uspto-grants-1986_09 |