Ammonia → Aminopyrazine carboxamide

HRID 646732Notes

Reaction equation

HRID 646732 reaction equation
[NH2:1][C:2]1[C:3]([C:8]([O:10]C)=O)=[N:4][CH:5]=[CH:6][N:7]=1.[NH3:12]>CO>[NH2:1][C:2]1[C:3]([C:8]([NH2:12])=[O:10])=[N:4][CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 72669Methyl 3-aminopyrazinecarboxylate

Product 1

HCID 280292Aminopyrazine carboxamideYield 97.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
112.5 °C

Procedure

A suspension of methyl 3-aminopyrazine-2-carboxylate (5 g, 32.6 mmol) and 150 mL of dry methanol saturated with anhydrous ammonia were heated in an autoclave at 110-115° C. for 24 h. Concentration and filtration afforded 3-aminopyrazine-2-carboxamide (4.4 g, 97.7% yield) as a yellow solid.

Workup

  1. concentrationConcentration and filtration

Sources & evidence

ORD record
ord-18874ded497546f18a4d5fbaeb33b899
Source dataset
uspto-grants-2010_04
Patent number
US07704995B2

Reaction notes

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