3,5-Dimethylphenol → 4-Chloro-1-(3,5-dimethylphenoxy)-2-butanol

Participants

Reaction Conditions

Reaction Steps

To a mixture of 245 g. (2 moles) of 3,5-dimethylphenol and 2 liters of 2N sodium hydroxide was added 2.5 moles of 1,4-dichlorobutanol with stirring at 65° C. overnight. The solid precipitate which separated on cooling was filtered and washed with water to neutrality. Recrystallization with isopropyl ether yielded 375 g. of white crystalline solid which melted at 74°-76° C.

Provenance & Evidence