Sulfuric Acid → trimethylpyruvic acid N-acetylamide

HRID 647239

Reaction equation

HRID 647239 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[C:8]([C:14]#[N:15])(=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10].S(=O)(=O)(O)[OH:17]>>[C:1]([NH:15][C:14](=[O:17])[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])=[O:13])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 945273,3-Dimethyl-2-oxobutanenitrile

Product 1

HCID 12769196trimethylpyruvic acid N-acetylamideYield 86.5%

Procedure

Firstly 25.6 g (0.25 mol) of acetic anhydride and then 27.8 g (0.25 mol) of pivaloyl cyanide were introduced, in each case at room temperature, into 49.0 g (0.5 mol) of initially introduced concentrated sulphuric acid. After the reaction mixture had been further stirred for 4 hours, 150 g of ice-water were added to it and it was thoroughly stirred. The precipitated reaction product was filtered off under suction, washed with 100 ml of water and dried. 37.0 g (86.5% of theory) of trimethylpyruvic acid N-acetylamide were obtained as colorless shiny platelets of melting point 82° to 84° C.

Workup

  1. stirringwas thoroughly stirred
  2. customThe precipitated reaction product
  3. filtrationwas filtered off under suction
  4. washwashed with 100 ml of water
  5. customdried

Sources & evidence

ORD record
ord-9e02003dfc9a44e48206f8ccd084de93
Source dataset
uspto-grants-1983_10
Patent number
US04408044

Linked notes

Loading…