HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 22847666, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 1H-Imidazole-5-carboxaldehyde, 2-butyl-1-[(2-chlorophenyl)methyl]- | HCID 10107530 | — |
| Reactant | (S)-Methyl 2-amino-3-(thiophen-2-yl)propanoate | HCID 10899351 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 22847666 | HCID 22847666 | — |
Reaction Steps
A solution of 2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-carboxaldehyde (0.6 g, 2.12 mmol), β-(2-thienyl)alanine methyl ester (0.4 g, 2.16 mmol) and toluene (25 ml) was refluxed under argon with a Dean-Stark water separator for 8 hours. The solvent was evaporated to an orange-red oil (1.1 g) of the title imine whose NMR was consistent with the structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05248689 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-7b25920dfe6144a1a723eec9437b7937 |
| Source note | uspto-grants-1993_09 |