4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride → 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoyl chloride hydrochloride

HRID 648512

Reaction equation

HRID 648512 reaction equation
[ClH:1].[CH2:2]([O:4][C:5]([C:7]1[CH:8]=[N:9][C:10]2[C:15]([C:16]=1[NH:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=1)=[CH:14][CH:13]=[C:12]([C:27]([F:30])([F:29])[F:28])[CH:11]=2)=[O:6])[CH3:3]>S(Cl)(Cl)=O>[ClH:1].[CH2:2]([O:4][C:5]([C:7]1[CH:8]=[N:9][C:10]2[C:15]([C:16]=1[NH:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([Cl:1])=[O:23])=[CH:20][CH:19]=1)=[CH:14][CH:13]=[C:12]([C:27]([F:30])([F:29])[F:28])[CH:11]=2)=[O:6])[CH3:3]

Participants

3

Reactant 1

HCID 138250354-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride

Product 1

HCID 138250374-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoyl chloride hydrochlorideYield 200.4%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

A suspension of 4-[[3-ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride (2.51 g) in thionyl chloride (25 ml) was stirred under reflux for 4 hours and concentrated to dryness in vacuo to give 4-[[3-ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoyl chloride hydrochloride (2.62 g) as yellow powder.

Workup

  1. temperatureunder reflux for 4 hours
  2. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-c8306702bfee473bab7017d92f61a2b7
Source dataset
uspto-grants-1988_04
Patent number
US04735952

Linked notes

Loading…