Dichloromethane → 4-(4-Chlorobenzoyl)-piperazin-1-yl-acetic acid morpholide hydrochloride

HRID 64870

Reaction equation

HRID 64870 reaction equation
[N:1]1([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=1[C:19](Cl)=[O:20].C(Cl)[Cl:27]>>[ClH:16].[Cl:27][C:24]1[CH:23]=[CH:22][C:18]([C:19]([N:4]2[CH2:3][CH2:2][N:1]([CH2:7][C:8]([N:10]3[CH2:11][CH2:12][O:13][CH2:14][CH2:15]3)=[O:9])[CH2:6][CH2:5]2)=[O:20])=[CH:17][CH:25]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 691102-Chlorobenzoyl chlorideHCID 1006221-(Morpholinocarbonylmethyl)piperazine

Product 1

HCID 867409864-(4-Chlorobenzoyl)-piperazin-1-yl-acetic acid morpholide hydrochloride

Procedure

5 g of piperazinoacetic acid morpholide and 4.2 g of chlorobenzoyl chloride are brought together in 50 ml of methylene chloride at 0° C. The mixture is stirred at room temperature for 2 hours and cooled again to 0° C., whereupon a precipitate separates out, and is recrystallised from isopropanol.

Workup

  1. temperaturecooled again to 0° C., whereupon a precipitate
  2. customis recrystallised from isopropanol

Sources & evidence

ORD record
ord-00c9c449b98d467ca6ce6714565bfd2c
Source dataset
uspto-grants-1986_09
Patent number
US04610984

Linked notes

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