HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzo(B)Thiophene → 2,3-Dihydrobenzo(b)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzo(B)Thiophene | HCID 7221 | — |
| Catalyst | Sodium amalgam | HCID 9837419 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,3-Dihydrobenzo(b)thiophene | HCID 78319 | — |
Reaction Steps
The dihydrobenzothiophenes are prepared as depicted in Chart D. A solution of a formula LX benzothiophene in water is stirred with excess sodium amalgam (NaHg) for 24 hr. After workup there is obtained the corresponding Formula LXI dihydrobenzothiophene. (See, e.g., D. T. Witiak, et al., J. Med. Chem. 14, 754 (1971).)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04611059 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-b72bcf250541411db5b39c9ed0780759 |
| Source note | uspto-grants-1986_09 |