4-Tert-butylcyclohexane-1-carboxylic acid → n-((5s)-3-(4-(1-{4-t-Butylcyclohexylcarbonyl}-1,2,5,6-tetrahydropyrid-4-yl)phenyl)-2-oxooxazolidin-5-ylmethyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	4-Tert-butylcyclohexane-1-carboxylic acid	HCID 136759	—
Reactant	N-((5S)-3-(4-(1,2,5,6-tetrahydropyrid-4-yl)phenyl)-2-oxooxazolidin-5-ylmethyl)acetamide	HCID 20638827	—
Product	n-((5s)-3-(4-(1-{4-t-Butylcyclohexylcarbonyl}-1,2,5,6-tetrahydropyrid-4-yl)phenyl)-2-oxooxazolidin-5-ylmethyl)acetamide	HCID 57235224	—

Reaction Steps

Using an analogous procedure to that described in Example 20, the TFA salt of Example 2 was reacted with 4-tert-butylcyclohexanecarboxylic acid in place of N-acetylglycine, to give the title compound. Yield=208 mg, 58%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06271383B1
Source dataset	uspto-grants-2001_08
ORD ID	ord-f5e914135cfd4454a320f3dca5b9378f
Source note	uspto-grants-2001_08