HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → isoamyl 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Benzoyl-6-(methylsulfanyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid | HCID 13687513 | — |
| Solvent | Isoamyl Alcohol | HCID 31260 | — |
| Product | isoamyl 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate | HCID 20235111 | — |
Reaction Steps
A solution of 300 mg of 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml of isoamyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue purified by chromatography on alumina, to yield isoamyl 5-benzoyl-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04612325 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-e4412cf6058946c0be3bb8a1147c64c7 |
| Source note | uspto-grants-1986_09 |