Methyl iodide → 7-Amino-2-methyl-3,4-dihydroisoquinolinium iodide
Reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[I:12][CH3:13]>CC(C)=O>[I-:12].[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N+:8]([CH3:13])=[CH:9]2)=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
7-amino-3,4-dihydroisoquinoline (0.40 g, 2.74 mmol) in acetone (125 ml) was treated with iodomethane (0.50 ml, 8.03 mmol) and left stirring at room temperature for 18 h. The resultant yellow precipitate was collected by filtration and dried in vacuo at ambient temperature (0.73 g, 92%). m/z (API)=161 (M)+
Workup
- waitleft
- filtrationThe resultant yellow precipitate was collected by filtration
- customdried in vacuo at ambient temperature (0.73 g, 92%)
Sources & evidence
- ORD record
- ord-a31009c6874141d691607b362acda856
- Source dataset
- uspto-grants-2001_08
- Patent number
- US06277861B1
Reaction notes
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