(1-Dimethylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester → (2S)-2-Amino-N,N-dimethyl-3-phenylpropanamide hydrochloride
Reaction equation
C(OC(=O)[NH:7][CH:8]([C:16](=[O:20])[N:17]([CH3:19])[CH3:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.[ClH:22].O1CCOCC1>>[ClH:22].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:16]([N:17]([CH3:19])[CH3:18])=[O:20]Participants
3
Conditions
- Temperature
- 25 °C
Procedure
(1-Dimethylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (8.6 g, 29 mmol) was dissolved in 4 M HCl-dioxane (110 ml) at 0° C. and the mixture stirred at 25° C. for 1 hour. The mixture was concentrated and the solids triturated with ether. Yield, 6.2 g, 92%; PBMS 193 (MH+, 100%).
Workup
- concentrationThe mixture was concentrated