6-Chlorobenzo[b]thiophene-2-sulfonyl chloride → 6-Chloro-benzo[b]thiophene-2-sulfonic acid (2-oxo-1-prop-2-ynyl-pyrrolidin-3-(s)-yl)amide

HRID 651661

Reaction equation

HRID 651661 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:9]=[C:8]([S:10](Cl)(=[O:12])=[O:11])[S:7][C:6]=2[CH:14]=1.Cl.[NH2:16][C@H:17]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]#[CH:24])[C:18]1=[O:25]>>[O:25]=[C:18]1[C@@H:17]([NH:16][S:10]([C:8]2[S:7][C:6]3[CH:14]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[CH:9]=2)(=[O:12])=[O:11])[CH2:21][CH2:20][N:19]1[CH2:22][C:23]#[CH:24]

Participants

3

Reactant 2

HCID 151586416-Chlorobenzo[b]thiophene-2-sulfonyl chlorideHCID 206807303-(S)-amino-1-prop-2-ynyl-pyrrolidin-2-one hydrochloride

Product 1

HCID 538925226-Chloro-benzo[b]thiophene-2-sulfonic acid (2-oxo-1-prop-2-ynyl-pyrrolidin-3-(s)-yl)amide

Procedure

The title compound is prepared as described in EXAMPLE 1, Part K using 6-chloro-benzo[b]thiophene-2-sulfonyl chloride and 3-(S)-amino-1-prop-2-ynyl-pyrrolidin-2-one hydrochloride as starting material. The crude product is isolated as a beige foam and used in the subsequent step without further purification.

Sources & evidence

ORD record
ord-05187c3376004192a615c0c17db4dc1e
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Linked notes

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