Thieno[3,2-b]pyridine-2-sulfonyl chloride → Thieno[3,2-b]pyridine-2-sulfonic acid (2-oxo-1-prop-2-ynyl-pyrrolidin-3-(S)-yl)-amide

HRID 651664

Reaction equation

HRID 651664 reaction equation
[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[S:10](Cl)(=[O:12])=[O:11].Cl.[NH2:15][C@H:16]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]#[CH:23])[C:17]1=[O:24]>>[O:24]=[C:17]1[C@@H:16]([NH:15][S:10]([C:2]2[S:1][C:9]3[C:4](=[N:5][CH:6]=[CH:7][CH:8]=3)[CH:3]=2)(=[O:12])=[O:11])[CH2:20][CH2:19][N:18]1[CH2:21][C:22]#[CH:23]

Participants

3

Reactant 2

HCID 18176395Thieno[3,2-b]pyridine-2-sulfonyl chlorideHCID 206807303-(S)-amino-1-prop-2-ynyl-pyrrolidin-2-one hydrochloride

Product 1

HCID 53755487Thieno[3,2-b]pyridine-2-sulfonic acid (2-oxo-1-prop-2-ynyl-pyrrolidin-3-(S)-yl)-amide

Procedure

The title compound is prepared as described in EXAMPLE 1, Part K using thieno[3,2-b]pyridine-2-sulfonyl chloride and 3-(S)-amino-1-prop-2-ynyl-pyrrolidin-2-one hydrochloride as starting material. The crude product is isolated as a white solid and used in the subsequent step without further purification.

Sources & evidence

ORD record
ord-ba8066981b134e7a974418d417bc6eb6
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Linked notes

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