Isopropylamine → HCID 13885084, compound
Reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[F:5][CH:6]([Cl:12])[C:7](OCC)=[O:8]>C(O)C.C(O)CO>[CH:1]([NH:4][C:7](=[O:8])[CH:6]([Cl:12])[F:5])([CH3:3])[CH3:2]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 11.8 grams (0.2 mole) isopropyl amine in 20 milliliters ethyl alcohol were added dropwise at 10°-15° C. with stirring to a solution of ethyl fluorochloroacetate and 5 drops of ethylene glycol in 80 milliliters ethyl alcohol. The solution was stirred at 10°-20° C. for 2 hours and was then stored at -15° C. for 3 days. At this time, the solution was evaporated to leave a liquid, 25.2 grams, nD30 1.4395, identified as the title compound by infrared and nuclear magnetic resonance spectroscopy.
Workup
- waitwas then stored at -15° C. for 3 days
- customAt this time, the solution was evaporated
- customto leave a liquid, 25.2 grams
Sources & evidence
- ORD record
- ord-52dc0d6660124f188cdacf971dec5896
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04670593
Reaction notes
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