Phosphoric Acid → HCID 20197207, compound
Reaction equation
[ClH:1].[CH2:2]([NH:6][CH:7]1[CH2:13][CH:12](O)[C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[O:9][CH2:8]1)[CH2:3][CH2:4][CH3:5].P(=O)(O)(O)O>>[ClH:1].[CH2:2]([NH:6][CH:7]1[CH:13]=[CH:12][C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[O:9][CH2:8]1)[CH2:3][CH2:4][CH3:5]Participants
3
Procedure
15.3 g 3-butylamino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol hydrochloride were stirred for four hours at room temperature in 80 ml of an 85 percent aqueous phosphoric acid solution. Subsequently, the solution was poured over 100 g of ice, and the mixture was worked up as described in Example 1. 12.1 g of 3-butylamino-2,3-dihydro-1-benzoxepine hydrochloride were obtained. Melting point: 138 degrees C.
Sources & evidence
- ORD record
- ord-9e4f83ee5949424f8a5eee9fb41b59a5
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04672062
Reaction notes
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