5-Amino-2'-deoxyuridine → 5-Diazo-deoxyuridine

HRID 652469

Reaction equation

[NH2:1][C:2]1[C:3](=[O:17])[NH:4][C:5](=[O:16])[N:6]([CH:15]=1)[C@@H:7]1[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[CH2:8]1.[N:18]([O-])=O.[Na+]>>[N+:1](=[C:2]1[CH2:15][N:6]([C@@H:7]2[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[CH2:8]2)[C:5](=[O:16])[NH:4][C:3]1=[O:17])=[N-:18]

Participants

Reactant 2

HCID 1110815-Amino-2'-deoxyuridine

HCID 23668193Sodium Nitrite

Product 1

HCID 186082155-Diazo-deoxyuridine

Procedure

acidifying said 5-amino-deoxyuridine compound and reacting the acidified product with sodium nitrite to produce a 5-diazo-deoxyuridine compound; and

Sources & evidence

ORD record: ord-1739582db5304f078ec5cb0d998487cf
Source dataset: uspto-grants-1987_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04672111

Linked notes

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