Methyl iodide → HCID 178480903, compound

HRID 65252

Reaction equation

HRID 65252 reaction equation
[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.[I:20][CH3:21]>CO>[I-:20].[OH:1][CH:2]([C:9]1[CH:10]=[CH:11][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:14]=1)[CH2:3][N+:4]1[CH:8]=[CH:7][N:6]([CH3:21])[CH:5]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13763390N-[4-(1-Hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide

Product 1

HCID 178480903HCID 178480903, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Heat a solution of 4.0 g (14.2 mmole) of (±)-N-[4-[1-hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide, 2 ml (32.1 mmole) of iodomethane and 50 ml methanol in a glass pressure tube to 80° C. for 24 hours. Remove the solvent in vacuo. Crystallize the residue from acetone. Recrystallize from acetone to provide the title compound.

Workup

  1. customRemove the solvent in vacuo
  2. customCrystallize the residue from acetone
  3. customRecrystallize from acetone

Sources & evidence

ORD record
ord-30a8001166504f31b5d5e17ea568ca6b
Source dataset
uspto-grants-1986_09
Patent number
US04613609

Linked notes

Loading…