Cyclopropylamine → HCID 53733396, compound
Reaction equation
Cl[CH:2]([CH2:19][CH2:20][CH2:21]Cl)[CH2:3][NH:4][C:5](=[O:18])[C:6]1[CH:11]=[C:10]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:9]=[CH:8][C:7]=1[O:16][CH3:17].[CH:23]1([NH2:26])[CH2:25][CH2:24]1>O>[CH:23]1([N:26]2[CH2:21][CH2:20][CH2:19][CH:2]2[CH2:3][NH:4][C:5](=[O:18])[C:6]2[CH:11]=[C:10]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:9]=[CH:8][C:7]=2[O:16][CH3:17])[CH2:25][CH2:24]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
36.9 g (0.1 mole) of N-(2,5-dichloropentyl)-2-methoxy-5-sulphamoyl-benzamide and 57 g of cyclopropylamine are placed in 250 ml bottle. They are brought to reflux for 6 hours, left to stand for 1 night then brought back to reflux for 5 hours. The suspension obtained is poured into 300 ml of water and 50 g of ice. The white precipitate is washed with water and dried in an oven at 60° C. It melts at 163° C. and weighs 29.5 g (83.6%). It is dissolved in 2 liters of acetonitrile and filtered in the presence of carbon black. The filtrate is left to crystallise. The crystals obtained are filtered, washed with acetonitrile and dried at 40° C. 67 g (yield 74.9%) of N-(1-cyclopropyl-2-pyrrolidinylmethyl)-2-methoxy-5-sulphamoylbenzamide is collected, melting at 180° C.