Pyridinium chloride → 2,3-Dichloro-4-hydroxy-4'-fluorobenzophenone

HRID 652880

Reaction equation

HRID 652880 reaction equation
[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([O:18]C)[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:5].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([OH:18])[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=1)=[O:5]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 201506312,3-Dichloro-4-methoxy-4'-fluorobenzophenone

Product 1

HCID 130157072,3-Dichloro-4-hydroxy-4'-fluorobenzophenone

Conditions

Temperature
200 °C

Procedure

A mixture of 39.5 g of 2,3-dichloro-4-methoxy-4'-fluorobenzophenone and 160 g of pyridine hydrochloride is heated at 200° C. for one hour. The reaction mixture is poured into ice water with stirring and a precipitate forms. The precipitate is filtered and dried for about 18 hours to yield 2,3-dichloro-4-hydroxy-4'-fluorobenzophenone.

Workup

  1. filtrationThe precipitate is filtered
  2. customdried for about 18 hours

Sources & evidence

ORD record
ord-6befd78396e1408d834f837ba11e8b56
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Linked notes

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