HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroquinone → 4-[(S)-2-methyl-1-butoxy]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroquinone | HCID 785 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Bromo-2-methylbutane, (+)- | HCID 5464167 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[(S)-2-methyl-1-butoxy]phenol | HCID 1490310 | 48% |
Reaction Steps
A reaction mixture of hydroquinone (18.2 grams); (S)-(+)-1-bromo-2-methylbutane (4.55 grams); anhydrous potassium carbonate (23 grams); and acetonitrile (250 mls.) was allowed to reflux for 40 hours. Flash chromatography using dichloromethane eluant yielded 2.6 grams (48%) of white crystals exhibiting a Fisher-Johns melting point of 44°-45° C. and having the structure ##STR24## confirmed by TLC, NMR, IR and mass spectral analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05132041 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-64837fe3886a4e81a4bbb9a562f4bde0 |
| Source note | uspto-grants-1992_07 |