(3-Bromoprop-1-yn-1-yl)benzene → 2-Methoxy-2-[3-(3-phenylprop-2-ynyloxy)phenyl]-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)but-1-yl methyl ether
Reaction equation
[CH3:1][O:2][CH2:3][C:4]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[CH:19]=1)([O:16][CH3:17])[CH2:5][CH2:6][C:7]1([CH3:15])[O:12][CH2:11][C:10]([CH3:14])([CH3:13])[CH2:9][O:8]1.[C:25]1([C:31]#[C:32][CH2:33]Br)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH3:1][O:2][CH2:3][C:4]([O:16][CH3:17])([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:33][C:32]#[C:31][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:19]=1)[CH2:5][CH2:6][C:7]1([CH3:15])[O:8][CH2:9][C:10]([CH3:14])([CH3:13])[CH2:11][O:12]1Participants
3
Procedure
Using the procedure described in Example 12, 2-(3-hydroxyphenyl)-2-methoxy-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)but-1-yl methyl ether was reacted with 3-phenylprop-2-ynyl bromide to give 2-methoxy-2-[3-(3-phenylprop-2-ynyloxy)phenyl]-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)but-1-yl methyl ether in 85% yield, as an oil.