5-Methyloxazolo[4,5-b]pyridin-2(3H)-one → 5-methyl-3-[3-(5-methylpyridin-2-yl)benzyl]-3H-oxazolo[4,5-b]-pyridin-2-one

HRID 655343

Reaction equation

HRID 655343 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH2:14]O)[CH:11]=[CH:12][CH:13]=2)=[N:6][CH:7]=1.[CH3:16][C:17]1[N:22]=[C:21]2[NH:23][C:24](=[O:26])[O:25][C:20]2=[CH:19][CH:18]=1>>[CH3:16][C:17]1[N:22]=[C:21]2[N:23]([CH2:14][C:10]3[CH:11]=[CH:12][CH:13]=[C:8]([C:5]4[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=4)[CH:9]=3)[C:24](=[O:26])[O:25][C:20]2=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 100120755-Methyloxazolo[4,5-b]pyridin-2(3H)-oneHCID 56604357(3-(5-Methylpyridin-2-yl)phenyl)methanol

Product 1

HCID 595647235-methyl-3-[3-(5-methylpyridin-2-yl)benzyl]-3H-oxazolo[4,5-b]-pyridin-2-one

Procedure

Reaction of [3-(5-methylpyridin-2-yl)phenyl]methanol with 5-methyl-3H-oxazolo[4,5-b]pyridin-2-one under Mitsunobu conditions gives the desired 5-methyl-3-[3-(5-methylpyridin-2-yl)benzyl]-3H-oxazolo[4,5-b]-pyridin-2-one, ESI 332 (M+H).

Sources & evidence

ORD record
ord-322d0eb93d354295b175707aa24d076f
Source dataset
uspto-grants-2011_12
Patent number
US08071593B2

Linked notes

Loading…