4-Amino-2,5-difluorobenzonitrile → 4-(Aminomethyl)-2,5-difluoroaniline
Reaction equation
[NH2:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:11])[CH:3]=1>[Ni].CO>[NH2:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([CH2:6][NH2:7])=[C:4]([F:11])[CH:3]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
4-amino-2,5-difluorobenzonitrile (400 mg) and Raney nickel Catalyst were added to methanol (20 ml) and the mixture was stirred under hydrogen atmosphere at room temperature for 18 hours. After confirming the completion of the reaction, the resulting mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The following procedure was carried out, using the concentrate which was not purified.
Workup
- customthe completion of the reaction
- filtrationthe resulting mixture was filtered through celite
- concentrationthe filtrate was concentrated under reduced pressure
- concentrationconcentrate which
- customwas not purified
Sources & evidence
- ORD record
- ord-741b233ad0c846098ea527fb4bc75a45
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071650B2
Reaction notes
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